For millions of people struggling with depression, traditional antidepressants have long been the first-line treatment. However, not everyone finds relief with these medications. Up to 30% of those with major depressive disorder (MDD) are diagnosed with treatment-resistant depression (TRD), meaning they have tried multiple antidepressants without significant improvement.
Until recently, patients prescribed Spravato® (esketamine) needed to take it alongside a daily oral antidepressant. That has now changed. The FDA has approved Spravato® as the first and only monotherapy for adults with TRD, making it a standalone treatment for those who have not responded to traditional medications.
This approval marks a major milestone in mental health care. With a faster onset of action and a unique mechanism targeting the brain’s glutamate system, Spravato® is redefining how we treat persistent depression. If you or a loved one has struggled with traditional antidepressants, Michigan Advanced Psychiatry offers Spravato® therapy and can help determine if it’s right for you.
How Do Traditional Antidepressants Work?
Most antidepressants—including selective serotonin reuptake inhibitors (SSRIs) like Prozac, Zoloft, and Lexapro—work by increasing levels of serotonin in the brain. Others, such as serotonin-norepinephrine reuptake inhibitors (SNRIs) like Cymbalta and Effexor, target both serotonin and norepinephrine.
While these medications can be effective, they have limitations. Downsides and unwanted side effects that many patients experience include:
- Delayed relief, requiring weeks before noticing improvements
- Nausea
- Weight changes
- Emotional numbness
- Sexual dysfunction.
For those with treatment-resistant depression, these medications may not provide the relief they need. This cycle can impact every aspect of life, from work and relationships to overall well-being. But it’s important to not give up, as Spravato® offers hope of relief.
Why Spravato® Works Differently
Unlike traditional antidepressants, Spravato® does not target serotonin or norepinephrine. Instead, it works on the NMDA receptor, a key part of the brain’s glutamate system, which plays a crucial role in mood regulation and neural connectivity. By stimulating this receptor, Spravato® helps create new neural pathways, making it easier for the brain to recover from the effects of depression.
The biggest advantage? Spravato® has a much faster onset than traditional antidepressants. Many patients experience improvement within hours or days, rather than waiting weeks for relief. This makes it a promising option for individuals with severe, persistent depression who need results quickly.
Another key change is that patients no longer need to take an oral antidepressant alongside Spravato®. The FDA’s new approval means it can now be used on its own—a major development for those who either did not respond well to traditional antidepressants or preferred to avoid them.
Spravato® is administered as a nasal spray in a clinical setting, under medical supervision. Patients remain for a short period after each treatment for monitoring, ensuring their safety and comfort. Learn more about Spravato® treatment at Michigan Advanced Psychiatry.
Spravato® vs. Traditional Antidepressants: Which Is Right for You?
The choice between Spravato® and traditional antidepressants depends on previous treatment history, symptom severity, and individual response to medication.
Traditional antidepressants work well for many, but they come with drawbacks, like delayed symptom relief and limited effectiveness for treatment-resistant depression. Unlike these, Spravato® provides faster, more targeted relief, especially for those who have not responded to multiple antidepressants.
For those dealing with long-term, treatment-resistant depression, Spravato® may offer a more effective solution. Schedule a consultation with our team to explore whether this breakthrough therapy is the right fit.
Who Is a Candidate for Spravato®?
Not everyone with depression is a candidate for Spravato®, but it may be an option for those who:
- Have been diagnosed with treatment-resistant depression
- Have tried at least two different antidepressants without success
- Need a faster-acting solution for severe depressive symptoms
At Michigan Advanced Psychiatry, our specialists provide personalized assessments to determine the best treatment plan for each patient.
Take the Next Step Toward Relief
If traditional antidepressants haven’t provided the relief you need, it may be time to explore a different approach. Michigan Advanced Psychiatry specializes in Spravato® therapy, offering personalized care to help you find lasting improvement. Our team will guide you through every step of the process and ensure you receive the best treatment for your needs.
Call today to schedule your appointment and take the first step toward real relief.
Ann Arbor: (734) 436-4886
Lansing: (517) 325-3776
Troy: (248) 885-8887
If you’re located in the Fort Wayne, Indiana area, visit our partner website to explore treatment options near you.